The endocannabinoid called arachidonoylethanolamine , better known as anandamide, was subsequently identified in 1992. A second endocannabinoid, called 2-arachidonoylglycerol (2-AG), was discovered in 1995. These regulatory changes have been driven, in part, by a growing evidence base for the therapeutic use of phytocannabinoids, particularly cannabidiol , the non-intoxicating compound found in hemp and marijuana . We’re passionate about helping women take control of their health through informed choices, and dedicated to providing the highest quality CBD-rich broad spectrum hemp supplements available, as an alternative to synthetic pharmaceuticals. Not only that, in almost every case of illness, there is some instance of endocannabinoid misregulation.
For example, it may affect intracellular signal transduction by disturbing neuronal membrane fluidity or by remodeling G-proteins associated with G-protein coupled receptors. CBD interacts with opioid, serotonin, adenosine, and GABA receptors, as well as non-G protein coupled receptors like PPARγ and ligand-gated ion channels such as TRPV1.
Phytocannabinoids are chemical compounds that occur naturally in plants. While phytocannabinoids can be found in hundreds of different plant species, they are present in the highest concentration in the cannabis plant. Though THC and CBD are the most well-known ones, there are over 100 phytocannabinoids, including CBN, CBG and CBC.
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It is involved in regulating practically every biological function including appetite, sleep, memory, reproduction, mood, sexual arousal, the immune system, and cell growth. Martin Lee from Project CBD likens the ECS to a dimmer switch, turning up or down cell activity in order to bring about homeostasis — the state of balance required for optimum health. Right now the ECS is working tirelessly to bring homeostasis, or balance, to our bodies and minds. It does this by regulating all physiological activity in the body — everything from sleep and appetite to memory and mood, including stress and anxiety. Every human has an endocannabinoid system and we can all enhance it, with or without cannabis.
The two most widely studied endocannabinoids are N-arachidonoylethanolamine and 2-arachidonolyglycerol (2-AG). Endocannabinoids are the signaling molecules of the endocannabinoid system. They are fatty acid neurotransmitters that coordinate and fine-tune intracellular biochemistry and intercellular communication across all physiological systems.
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Other core homeostatic processes include cell counts and size, blood sugar, oxygen and sleep. Homeostasis is defined by the OED as “the tendency towards a relatively stable equilibrium between interdependent elements, especially as maintained by physiological processes.” Let’s break that down. When your body is healthy, it means that your internal environment is balanced. The meaning of homeostasis is when your biological systems are stable despite disturbances from external CBD oil factors.
Currently, studies indicate there are different types of interactions between the ECS and different phytocannabinoids. An easy example is CBD, whose use does not activate receptors in the same way as, for example, THC.
CB1, the first receptor to be discovered, has been under the microscope for much longer so we have a lot more information. The human body needs a precisely tuned environment to function optimally. Our body temperature, for instance, is closely monitored and regulated through behavior. If that temperature fluctuates by one degree, we feel that imbalance by shivering or sweating. Falling out of balance can lead to many negative repercussions, including disease.
- These discoveries triggered an explosion of research exploring the endocannabinoid system.
- Anandamide’s main focus is to activate CB1 receptor, however, it does have a lower tendency towards the CB2 receptor.
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- The system has been implicated in multiple physiological functions and we now have valuable knowledge about the pharmacology, biochemistry, and clinical effects of endocannabinoids.
- The two primary endocannabinoids produced by the human body interact directly with these receptors.
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Sometimes this can be a cause of disease, while in others, it’s a sign that the body is trying to heal itself. The ECS is a vast communication network with the purpose of correcting any imbalances in our bodies and minds.